Abstract
Background
Intra-articular administration of adipose tissue-derived stem cells (ADSC) is an alternative
treatment option for knee osteoarthritis (OA) after conventional treatment fails;
however, the clinical results related to the severity of OA grade and changes of cartilage
volumes after the administration of ADSC is unknown. This study aimed to determine
1) clinical outcomes after the ADSC administration in knee OA with consideration of
radiographic OA grades and 2) changes in cartilage volumes after ADSC administration.
Methods
This observational study included 86 knees from 51 patients who underwent intra-articular
administration of cultured ADSC; 47 patients (80 knees) completed follow-up for 6
months (follow-up rate: 93%). The Knee injury and Osteoarthritis Outcome Scores (KOOS)
were reported at baseline and 1, 3, and 6 months after the administration. The efficacy
rate in the Outcome Measures in Arthritis Clinical Trials-Osteoarthritis Research
Society International (OMERACT-OARSI) was evaluated using the KOOS. Cartilage volume
of the knee joint was measured using quantitative 3-dimensional magnetic resonance
imaging (3D-MRI) software at baseline and 6 months in 52 knees in 31 patients (follow-up
rate: 61%).
Results
All items on the KOOS except “sports/recreation” improved significantly at 6 months
with more significance in knees with a Kellgren–Lawrence (KL) grade 2 or 3 compared
with KL grade 4 knees. The OMERACT-OARSI responder at 6 months was significantly greater
in knees with KL grade 2 or 3 (64%) than in knees with KL grade 4 (42%, p = 0.045).
Cartilage volume changes varied among patients and were not related to the changes
in KOOS after ADSC administration.
Conclusions
Intra-articular administration of ADSC in knee OA improved KOOS at 6 months. The effects
were more significant in knees with KL grade 2 or 3 than with KL grade 4. Changes
in KOOS were not related to change in cartilage volumes after ADSC administration.
Abbreviations:
OA (osteoarthritis), ADSC (adipose tissue-derived stem cell), MSC (mesenchymal stem cell), KOOS (Knee injury and Osteoarthritis Outcome Score), MRI (magnetic resonance imaging), K-L (Kellgren–Lawrence), OMERACT-OARSI (Outcome Measures in Arthritis Clinical Trials-Osteoarthritis Research Society International)To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
December 21,
2021
Received in revised form:
November 13,
2021
Received:
August 30,
2021
Identification
Copyright
© 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved.
